Formulation, Development and Characterization of Osmotic Tablets Containing Acyclovir

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Harshkumar Brahmbhatt, Lavande J. P., Vikas Vasant Patil, Imran A. Sheikh, Rohit, Chamundeswara Srinivasa Akash Kalla, Kaynaz Hussain, Rajeev Ranjan


The primary objective of this review was to make and test permeable osmotic tablets that can expand with controlled porosity for the treatment of herpes simplex. This formulation strives to improve bioavailability, reduce useful organ recurrence, eliminate unwanted design drugs, and improve patient consistency. Acyclovir is a manufactured simple of a purine nucleoside that is especially initiated by thymidine kinase, which is delivered by the Herpes Simplex Infection (HSV). It hinders viral DNA polymerases and fills in as a chain eliminator. Direct pressure was the strategy used to make the tablets, which were then profound covered to make a sum of nine formulations (F1-F9). The produced granules' flow and compression properties were assessed before compression. Also considered for the in vitro drug release investigation was a prepared osmotic drug delivery device.  During pill disintegration, the coating did not exhibit any signs of leaking and remained stable. The range of the coated tablet's weight increase percentage was determined to be 1.98–2.40%. Semipermeable membrane has a 240 m thickness and can tolerate pressure during disintegration. In addition, checking electron microscopy (SEM) was utilized to look at the surface design of the broke up covering film and to identify the arrangement of pores on the film. According to the prescribed ICH requirements, accelerated stability experiments for the improved formulation were carried out for one month. When formulas were examined for drug concentration and in vitro dissolution experiments, it was shown that they remained stable for a month.


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