Comparative Evaluation of Paediatric Antibiotic Dosing Guidelines: A Focus on Practical Implementation and Clinical Outcomes

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Nawaf Al-Dajani


Background: Pediatric antibiotic dosing guidelines play a crucial role in ensuring appropriate and effective treatment for young patients. However, significant variations exist among these guidelines, including dosing regimens, age-specific considerations, and available formulations. Adherence to these guidelines by healthcare professionals is essential to optimize patient outcomes and mitigate risks associated with pediatric antibiotic therapy.

Aims: This study aimed to identify and describe the variations in pediatric antibiotic dosing guidelines, evaluate the adherence of healthcare professionals to these guidelines, and examine the correlation between adherence and clinical outcomes.

Methods: An extensive literature review was conducted to identify pediatric antibiotic dosing guidelines from reputable organizations and national healthcare agencies. The identified guidelines were analyzed to determine variations in dosing regimens, age-specific considerations, and available formulations. Retrospective analysis was performed to assess the adherence rates of healthcare professionals, including physicians, nurses, and pharmacists. The correlation between guideline adherence and clinical outcomes, such as treatment efficacy, adverse drug events, and antimicrobial resistance, was examined.

Results: The review of pediatric antibiotic dosing guidelines revealed significant variations in dosing regimens, age-specific considerations, and available formulations. Adherence rates among healthcare professionals varied, with physicians demonstrating the highest adherence (80%), followed by pharmacists (75%) and nurses (65%). Overall, the average adherence rate was 73%. Higher adherence levels were associated with improved treatment efficacy, reduced occurrence of adverse drug events, and decreased antimicrobial resistance. In instances where healthcare professionals demonstrated high adherence levels (≥90%), treatment efficacy reached 92%, with minimal adverse events (7%) and antimicrobial resistance development (5%). Moderate adherence levels (70-89%) were still associated with favorable treatment efficacy (82%), while lower adherence levels (<70%) were linked to decreased treatment efficacy (68%), increased adverse events (20%), and higher antimicrobial resistance (15%).

Conclusion: This study highlights the variations in pediatric antibiotic dosing guidelines and the importance of consistent adherence among healthcare professionals. Adhering to evidence-based guidelines significantly enhances treatment efficacy, minimizes adverse drug events, and combats antimicrobial resistance in pediatric patients. Promoting adherence practices across all healthcare providers is crucial for improving patient outcomes and optimizing the effectiveness of pediatric antibiotic therapy.


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